Phenotypes Associated with This Genotype

Genotype
MGI:3851170

• Allelic Composition: Kcnip3^tm1Pngr/Kcnip3^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:74345 )

N • mice display normal locomotor activities, motor skills and coordination, anxiety, and spatial learning and memory

abnormal motor capabilities/coordination/movement ( J:74345 )

• mice exhibit more hind limb placement errors in the grid-walking task compared with wild-type mice indicating mild impairment of gross motor skills

• however, fine motor skills involving fore limbs are normal

abnormal nociception after inflammation ( J:74345 )

• mechano-sensitivity following inflammation induced by capsaicin or carrageenan is decreased compared to in similarly treated wild-type mice

• however, nor-BNI treatment restores pain response in the carrageenan and formalin models

hypoalgesia ( J:74345 )

• mice exhibit decreased neuropathic pain behavior compared with similarly treated wild-type mice

• however, treatment with nor-BNI decreases the neuropathic pain threshold

hyporesponsive to tactile stimuli ( J:74345 )

• mice exhibit increased threshold required to elicit withdrawal of hind paw in response to mechanical pressure compared with wild-type mice

• however, treatment with naloxone or nor-BNI decreases pain threshold

increased chemical nociceptive threshold ( J:74345 )

• in chemically mediated visceral pain tests, mice exhibit reduced response compared with similarly treated wild-type mice

• licking following administration of capsaicin is deceased compared to in similarly treated wild-type mice

increased thermal nociceptive threshold ( J:74345 )

• mice exhibit longer latency to withdrawal in a tail-flick test compared with wild-type mice

• however, treatment with naloxone or nor-BNI decreases pain threshold