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Phenotypes Associated with This Genotype
Genotype
MGI:3850822
Allelic
Composition
Ightm2.1(Tag)Rwhe/Igh+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2.1(Tag)Rwhe mutation (0 available); any Igh mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• spleen size is increased with age due to the emergence of a monoclonal B cell population

neoplasm
• the expansion of a monoclonal B cell population in these mice is indicative of leukemia

immune system
• spleen size is increased with age due to the emergence of a monoclonal B cell population
• as mice age, a large population emerges of monoclonal B cells preferentially expressing the wild-type allele
• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm
• as mice age, the number of B cells in the blood increase due to the emergence of a monoclonal population
• about 60% of mice with a monoclonal B cell population display lymph node hyperplasia with numbers being up to 15 fold higher

hematopoietic system
• spleen size is increased with age due to the emergence of a monoclonal B cell population
• as mice age, a large population emerges of monoclonal B cells preferentially expressing the wild-type allele
• these monoclonal B cells are larger in size and number, and have clumped chromatin with little cytoplasm
• as mice age, the number of B cells in the blood increase due to the emergence of a monoclonal population


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory