Phenotypes for Man2a1 Man2a2 MGI:3850629 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Man2a1^tm1Jxm/Man2a1^tm1Jxm Man2a2^tm1Mfu/Man2a2^tm1Mfu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1^tm1Jxm mutation (1 available); any Man2a1 mutation (62 available)
Man2a2^tm1Mfu mutation (0 available); any Man2a2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:111055 )

• some losses between E15 and E18

neonatal lethality, incomplete penetrance ( J:111055 )

• most die shortly after birth

postnatal lethality, incomplete penetrance ( J:111055 )

• very few survive to 3 weeks

respiratory system

abnormal pulmonary alveolus morphology ( J:111055 )

• reduced alveolar air space

abnormal pulmonary alveolus epithelial cell morphology ( J:111055 )

• thicker pulmonary epithelium layer

abnormal breathing pattern ( J:111055 )

• newborns actively gasp for air

• fail to breath properly

liver/biliary system

abnormal liver morphology ( J:111055 )

• frequently show liver damage

• E15 liver cells with abnormal vacuoles and enlarged mitochondria

renal/urinary system

abnormal proximal convoluted tubule morphology ( J:111055 )

• E15 cells with abnormal vacuoles and enlarged mitochondria

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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