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Phenotypes Associated with This Genotype
Genotype
MGI:3850627
Allelic
Composition
Man2a1tm1Jxm/Man2a1tm1Jxm
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1tm1Jxm mutation (1 available); any Man2a1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• small but significant increase in mortality by 18 months (J:74579)
• small but significant increase in mortality by 18 months (J:74579)

hematopoietic system
• mild to moderate (J:41621)
• mild to moderate (J:41621)
• variable red blood cell size (J:41621)
• variable red blood cell size (J:41621)
• increase as kidney disease develops (J:74579)
• increase as kidney disease develops (J:74579)
• severity of reticulocytosis increases with age (J:41621)
• high levels of reticulocytes in peripheral blood, up to 30% (J:41621)
• high levels of reticulocytes in peripheral blood, up to 30% (J:41621)
• severity of reticulocytosis increases with age (J:41621)
• increased numbers of erythroblasts in bone marrow (J:41621)
• increased numbers of erythroblasts in bone marrow (J:41621)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• marked splenomegaly at all ages examined (J:41621)
• marked splenomegaly at all ages examined (J:41621)
• reduced osmotic fragility (J:41621)
• reduced osmotic fragility (J:41621)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)

renal/urinary system
• an expanded mesangial matrix often causes obstruction of capillary lumina (J:74579)
• an expanded mesangial matrix often causes obstruction of capillary lumina (J:74579)
• extensive scarring of the kidneys develops (J:74579)
• extensive scarring of the kidneys develops (J:74579)
• normal to at least 3 months of age (J:74579)
• normal to at least 3 months of age (J:74579)
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• in about 60% of mice (J:74579)
• in about 60% of mice (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)

liver/biliary system
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)

respiratory system
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)

immune system
N
• B and T cell development and function normal (J:74579)
• B and T cell development and function normal (J:74579)
• increase as kidney disease develops (J:74579)
• increase as kidney disease develops (J:74579)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• elevated erythroid precursors (J:74579)
• lymphoid tissues are otherwise normal (J:74579)
• marked splenomegaly at all ages examined (J:41621)
• marked splenomegaly at all ages examined (J:41621)
• circulating immune complexes become elevated (J:74579)
• circulating immune complexes become elevated (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• starting at 10 weeks of age (J:74579)
• antinuclear antibody in about 60% of mice having hematuria (J:74579)
• antinuclear antibody in about 60% of mice having hematuria (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)
• in more than 80% of homozygotes at 12 months of age (J:74579)
• elevated Ig and C3 deposition in kidney glomeruli by 6 months (J:74579)
• frequently elevated mononuclear leukocyte infiltrates (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)
• mononuclear leukocyte infiltrates are frequently elevated (J:74579)

homeostasis/metabolism
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• low or moderate (J:74579)
• in about 30% of homozygotes (J:74579)
• in about 60% of mice (J:74579)
• in about 60% of mice (J:74579)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory