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Phenotypes Associated with This Genotype
Genotype
MGI:3850548
Allelic
Composition
Il13tm1.1Anjm/Il13tm1.1Anjm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm1.1Anjm mutation (0 available); any Il13 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions
• Th2 cells are produced under chronic N. brasiliensis infection
• much fewer Th2 cells are found in vitro
• total IgE levels are decreased 5- to 20- fold
• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls
• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to controls

homeostasis/metabolism
• IL-13 are absent in these mice

immune system
• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions
• Th2 cells are produced under chronic N. brasiliensis infection
• much fewer Th2 cells are found in vitro
• total IgE levels are decreased 5- to 20- fold
• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls
• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to controls
• IL-13 are absent in these mice
• IFN-gamma secretion is 2-fold compared to controls when CD4 T cells are restimulated compared to controls
• IL-10 secretion is reduced 2-fold compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions
• IL-4 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions
• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-4 response than controls
• IL-5 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions
• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-5 response than controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory