Mouse Genome Informatics
hm
    Sgcbtm1Oza/Sgcbtm1Oza
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
muscle
• at 3 weeks, mononuclear cell infiltration within muscles occurs unlike in wild-type mice
• mice exhibit muscular hypertrophy (tibialis anterior, gastrocnemius, and quadriceps femoris) compared with wild-type mice
• mice exhibit stripes of degenerating muscle fibers unlike wild-type mice that worsens with age
• muscle degeneration is observed at 2 weeks of age along with muscle regeneration
• at 2 weeks in the soleus and tibialis anterior
• at 8 weeks in the quadricep
• with extensive muscle degeneration and regeneration

growth/size
• at 8 weeks, mice appear brawny with hypertrophic shoulders and limbs compared with wild-type mice
• at 20 weeks, female mice are hypertrophic and larger with increased body weight compared with wild-type mice
• at 20 weeks, female mice are hypertrophic and larger with increased body weight compared with wild-type mice

cardiovascular system
• at 56 weeks, many scattered patches of fibrosis are observed in the heart wall unlike in wild-type mice

immune system
• at 3 weeks, mononuclear cell infiltration within muscles occurs unlike in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Limb-Girdle, Type 2E; LGMD2E 604286 J:57590