About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3850440
Allelic
Composition
Cdkn2atm2Brn/Cdkn2atm2Brn
Nf2tm2Gth/Nf2tm2Gth
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2Brn mutation (2 available); any Cdkn2a mutation (31 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• in 4% of mice following adenoviral cre treatment

muscle
• in 4% of mice following adenoviral cre treatment

mortality/aging
• following adenoviral cre treatment, median survival time is 220 days

neoplasm
• following adenoviral cre treatment, 83% of mice develop highly invasive thoracic tumors (including malignant mesotheliomas, 45 of 57; rhabdomyosarcomas, 3 of 57; and schwannomas, 1 of 57)
• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus
• following adenoviral cre treatment, 4% of mice develop aspecific tumors not induced by adeno-cre treatment
• following adenoviral cre treatment, 70% of mice develop aggressive malignant mesotheliomas, which is higher than in mice carrying other combinations of Cdkn2atm2Brn, Nf2tm2Gth, and Trp53tm1Brn alleles
• in 4% of mice following adenoviral cre treatment
• following adenoviral cre treatment, 7% mice develop monocytic myeloid leukemias

liver/biliary system
• following adenoviral cre treatment, 42% of mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

Mouse Models of Human Disease
OMIM ID Ref(s)
Mesothelioma, Malignant; MESOM 156240 J:132943


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory