Phenotypes Associated with This Genotype

Genotype
MGI:3850438

• Allelic Composition: Tg(Prl-tTA)6-5Jek/0; Tg(tetO-Egfr*)2-9Jek/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:68692 )

N • rates of growth and weight gain in transgenic mice after doxycycline-withdrawalare identical to wild-type mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:68692 )

N • pituitary size and pituitary gross morphology in transgenic mice after doxycycline withdrawal are the same as wild-type mice; cell proliferation in the pituitary shows no difference compared to controls

reproductive system

reproductive system phenotype ( J:68692 )

N • ability of transgenic mice to lactate is not impaired

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:68692 )

N • pituitary hormones in transgenic mice after doxycycline-withdrawal show normal distribution patterns compared to wild-type mice; prolactin (PRL) shows a normal distribution pattern before and during pregnancy