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Phenotypes Associated with This Genotype
Genotype
MGI:3850371
Allelic
Composition
Pink1tm1Aub/Pink1tm1Aub
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Aub mutation (2 available); any Pink1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite decreased dopamine levels, no loss of dopaminergic neurons is seen at 18 months of age
• unlike in Parkinson's disease patients, Lewy bodies are not detected in the brainstem and substantia nigra

behavior/neurological
N
• unlike in human patients with early stage sporadic Parkinson's disease, acoustic startle reflexes are not impaired
• decrease in total distance covered, horizontal activity, movement time, stereotypy count and center distance in an open field test beginning at 16 months of age

growth/size/body
• weigh up to 19% less than controls at 1 year of age

cellular
N
• unlike in Drosophila pink1 null mutants, no defects in mitochondrial fission are detected
• decrease in ATP levels in dissociated neurons under basal conditions
• liver mitochondrial membrane potential shows a progressive age related reduction
• assays indicate age-related impairment in liver mitochondrial import reactions
• liver mitochondrial membrane potential shows a progressive age related reduction
• respiratory complex activity of purified liver mitochondria from 18 month old mice is significantly reduced compared to controls

endocrine/exocrine glands
N
• unlike in human patients with early stage sporadic Parkinson's disease, increased sweating is not seen

homeostasis/metabolism
• decreased dopamine levels in the striatum at 9 and 22-24 months of age

mortality/aging
• mortality rate is reduced as compared to wild-type controls
• most mice live to 450 days, some live to greater than 600 days

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 6 DOID:0060369 OMIM:605909
J:150206


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory