Mouse Genome Informatics
cx
    Tg(KRT5-tTA)1216Glk/0
Tg(tetO-Il13)1Tazh/0

B6.Cg-Tg(KRT5-tTA)1216Glk Tg(tetO-Il13)1Tazh
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• 4-fold in the skin following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal and stimulation with anti-CD3/CD28, lymphocytes and peripheral blood mononuclear cells produce more IL13 than wild-type cells
• following doxycycline withdrawal, IL4 lymphocyte production is increased compared to in wild-type mice
• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice

cardiovascular system
• following doxycycline withdrawal, mice exhibit an increase in subcutaneous blood vessel formation compared to in wild-type mice

hematopoietic system
• 4-fold in the skin following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal

homeostasis/metabolism
• spongiosis following doxycycline withdrawal
• following doxycycline withdrawal, mice develop skin fibrosis unlike wild-type mice

integument
• following doxycycline withdrawal, mice develop skin fibrosis unlike wild-type mice
• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice
• following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal
• following doxycycline withdrawal, skin lesions progress and become extensive including dry lichenified skin lesions unlike in wild-type mice
• following doxycycline withdrawal, mice exhibit skin crusting, excoriation, bacterial pyoderma, and erosions in the skin mostly on the back and abdominal areas unlike wild-type mice
• spongiosis following doxycycline withdrawal
• following doxycycline withdrawal, mice exhibit pruritus unlike wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Dermatitis, Atopic 603165 J:150232