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Phenotypes Associated with This Genotype
Genotype
MGI:3850190
Allelic
Composition
Tg(KRT5-tTA)1216Glk/0
Tg(tetO-Il13)1Tazh/0
Genetic
Background
B6.Cg-Tg(KRT5-tTA)1216Glk Tg(tetO-Il13)1Tazh
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 4-fold in the skin following doxycycline withdrawal (J:150232)
• 4-fold in the skin following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal and stimulation with anti-CD3/CD28, lymphocytes and peripheral blood mononuclear cells produce more IL13 than wild-type cells (J:150232)
• following doxycycline withdrawal and stimulation with anti-CD3/CD28, lymphocytes and peripheral blood mononuclear cells produce more IL13 than wild-type cells (J:150232)
• following doxycycline withdrawal, IL4 lymphocyte production is increased compared to in wild-type mice (J:150232)
• following doxycycline withdrawal, IL4 lymphocyte production is increased compared to in wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice (J:150232)

cardiovascular system
• following doxycycline withdrawal, mice exhibit an increase in subcutaneous blood vessel formation compared to in wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit an increase in subcutaneous blood vessel formation compared to in wild-type mice (J:150232)

hematopoietic system
• 4-fold in the skin following doxycycline withdrawal (J:150232)
• 4-fold in the skin following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)

homeostasis/metabolism
• spongiosis following doxycycline withdrawal (J:150232)
• spongiosis following doxycycline withdrawal (J:150232)

integument
• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit increased numbers of mononuclear cells and eosinophils infiltrating the subepidermal, intradermal, and perivascular spaces of the skin unlike in wild-type mice (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal, skin lesions progress and become extensive including dry lichenified skin lesions unlike in wild-type mice (J:150232)
• following doxycycline withdrawal, skin lesions progress and become extensive including dry lichenified skin lesions unlike in wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit skin crusting, excoriation, bacterial pyoderma, and erosions in the skin mostly on the back and abdominal areas unlike wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit skin crusting, excoriation, bacterial pyoderma, and erosions in the skin mostly on the back and abdominal areas unlike wild-type mice (J:150232)
• spongiosis following doxycycline withdrawal (J:150232)
• spongiosis following doxycycline withdrawal (J:150232)
• following doxycycline withdrawal, mice develop skin fibrosis unlike wild-type mice (J:150232)
• following doxycycline withdrawal, mice develop skin fibrosis unlike wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit pruritus unlike wild-type mice (J:150232)
• following doxycycline withdrawal, mice exhibit pruritus unlike wild-type mice (J:150232)

Mouse Models of Human Disease
OMIM ID Ref(s)
Dermatitis, Atopic 603165 J:150232


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory