Mouse Genome Informatics
cn
    Nlrp3tm2Hhf/Nlrp3+
Tg(CAG-cre/Esr1*)5Amc/?

involves: 129/Sv * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro
• bone marrow derived dendritic cells (DCs) spontaneously secrete high levels of IL1-beta in response to cold (32 degrees) incubation
• DCs also hypersecrete the mature form of IL-1beta in response to activation
• the maximal response is 150-fold greater than controls
• DCs are able to secrete IL1-beta without the presence of exogenous ATP

hematopoietic system
• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro

Mouse Models of Human Disease
OMIM IDRef(s)
Familial Cold Autoinflammatory Syndrome 1; FCAS1 120100 J:150054