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Phenotypes Associated with This Genotype
Genotype
MGI:3849867
Allelic
Composition
Glis3tm1Hiha/Glis3tm1Hiha
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glis3tm1Hiha mutation (1 available); any Glis3 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 5 days of birth (J:150077)
• survival may be extended up to P9 when separated from wild-type and heterozygous littermates (J:150077)
• die within 5 days of birth (J:150077)
• survival may be extended up to P9 when separated from wild-type and heterozygous littermates (J:150077)

homeostasis/metabolism
• at P0, P1, and P7 (J:150077)
• at P0, P1, and P7 (J:150077)
• glucose intolerant (J:150077)
• glucose intolerant (J:150077)

renal/urinary system
• at P7, tiny cysts can be seen in the nephrogenic zone of the cortex (J:150077)
• at P7, tiny cysts can be seen in the nephrogenic zone of the cortex (J:150077)
• at P0, large cysts are seen in the intermediate area between the cortex and pelvis (J:150077)
• some cysts originate from Bowman's capsules (J:150077)
• at P7, cysts in the intermediate are increased in size and tiny cysts can be seen in the nephrogenic zone of the cortex (J:150077)
• at P0, large cysts are seen in the intermediate area between the cortex and pelvis (J:150077)
• some cysts originate from Bowman's capsules (J:150077)
• at P7, cysts in the intermediate are increased in size and tiny cysts can be seen in the nephrogenic zone of the cortex (J:150077)

endocrine/exocrine glands
• histology suggests hypothyroidism (J:150077)
• histology suggests hypothyroidism (J:150077)
• RT-PCR analysis indicates reduced expression of pancreatic hormones (J:150077)
• RT-PCR analysis indicates reduced expression of pancreatic hormones (J:150077)

growth/size/body
• display severe ateliosis despite presence of milk in the stomach (J:150077)
• display severe ateliosis despite presence of milk in the stomach (J:150077)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism 610199 J:150077


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory