Mouse Genome Informatics
hm
    Glis3tm1Hiha/Glis3tm1Hiha
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• die within 5 days of birth
• survival may be extended up to P9 when separated from wild-type and heterozygous littermates

homeostasis/metabolism
• glucose intolerant

renal/urinary system
• at P7, tiny cysts can be seen in the nephrogenic zone of the cortex
• at P0, large cysts are seen in the intermediate area between the cortex and pelvis
• some cysts originate from Bowman's capsules
• at P7, cysts in the intermediate are increased in size and tiny cysts can be seen in the nephrogenic zone of the cortex

endocrine/exocrine glands
• RT-PCR analysis indicates reduced expression of pancreatic hormones
• histology suggests hypothyroidism

growth/size/body
• display severe ateliosis despite presence of milk in the stomach

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism 610199 J:150077