Phenotypes Associated with This Genotype

Genotype
MGI:3849837

• Allelic Composition: Actg1^tm1.1Erv/Actg1^tm1.1Erv
• Genetic Background: B6.129-Actg1^tm1.1Erv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:150067 )

• some mice die prematurely

perinatal lethality, incomplete penetrance ( J:150067 )

• only one third of expected mice are born

hearing/vestibular/ear

decreased outer hair cell stereocilia number ( J:150067 )

• at 16 weeks, outer hair stereocilia are 50% degenerated or absent unlike in wild-type mice

• within the hair bundle, stereocilia are missing or shortened unlike in wild-type mice

• however, remaining stereocilia are normal

increased or absent threshold for auditory brainstem response ( J:150067 )

• progressive, beginning at 16 weeks of age

impaired hearing ( J:150067 )

• beginning at 16 weeks of age

deafness ( J:150067 )

• at 24 weeks

growth/size/body

decreased body weight ( J:150067 )

• 20% lower than wild-type mice

nervous system

decreased outer hair cell stereocilia number ( J:150067 )

• at 16 weeks, outer hair stereocilia are 50% degenerated or absent unlike in wild-type mice

• within the hair bundle, stereocilia are missing or shortened unlike in wild-type mice

• however, remaining stereocilia are normal

digestive/alimentary system

digestive/alimentary phenotype ( J:150067 )

N • intestinal microvilli are normal