Phenotypes Associated with This Genotype

Genotype
MGI:3849567

• Allelic Composition: Foxa2^tm1Dnl/Foxa2^tm1Dnl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:19896 )

• all die between E9.5 and E13

embryo

abnormal endoderm development ( J:19896 )

• at E9.5, endodermal cells are present but have not invaginated to form the gut tube

decreased embryo size ( J:19896 )

• at E9.5

abnormal embryonic tissue morphology ( J:19896 )

• at E7.5 the embryo has a tubular appearance and maintains little contact with the extraembryonic tissues

• at E9.5 embryos are either minute with few externally distinguishable landmarks or small, showing increased elongation compared to minute embryos but decreased compared to control littermates

abnormal chordamesoderm morphology ( J:19896 )

• expression analysis indicates that notochord development is not initiated

abnormal paraxial mesoderm morphology ( J:19896 )

• at E9.5 in many cases the paraxial mesoderm forms a continuous mass of tissue that traverses the midline under the neural tube

abnormal neural tube morphology ( J:19896 )

• the neural tube is closed at E9.5 but the dorsal and ventral regions appear abnormal with a high density of pyknotic nuclei primarily in the dorsal regions and an increase in thickness in the ventral regions

absent floor plate ( J:19896 )

• at E9.5, expression analysis indicates failure of differentiation of floor plate cells at all axial levels

absent notochord ( J:19896 )

• at E8.5 and E9.5

• expression analysis indicates that notochord development is not initiated

absent primitive node ( J:19896 )

• lack a distinct node at E7.5 and E8.5

abnormal somite development ( J:19896 )

• at E9.5 fewer than 10 somites are seen at the trunk level compared to more than 20 in control littermates

• at E9.5 somites are disarranged and in many cases the bilateral separation of segmented mesoderm is lost

cellular

abnormal cell death ( J:19896 )

• at E9.5 embryos contain increased numbers of dying cells

abnormal neuron differentiation ( J:19896 )

• at E9.5, expression analysis indicates absence of motor neuron differentiation in the ventral region of the neural tube

nervous system

abnormal nervous system development ( J:19896 )

• at E8.5 neural tissues are disordered and have prominent ridges

abnormal neuron differentiation ( J:19896 )

• at E9.5, expression analysis indicates absence of motor neuron differentiation in the ventral region of the neural tube

abnormal neural tube morphology ( J:19896 )

• the neural tube is closed at E9.5 but the dorsal and ventral regions appear abnormal with a high density of pyknotic nuclei primarily in the dorsal regions and an increase in thickness in the ventral regions

absent floor plate ( J:19896 )

• at E9.5, expression analysis indicates failure of differentiation of floor plate cells at all axial levels

vision/eye

abnormal eye development ( J:19896 )

• fail to show signs of eye differentiation at E9.5

growth/size/body

decreased embryo size ( J:19896 )

• at E9.5