Phenotypes Associated with This Genotype

Genotype
MGI:3849480

• Allelic Composition: Gpr68^tm1Yaxu/Gpr68^tm1Yaxu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Brown adipose tissue abnormality in Gpr68^tm1.1Yaxu/Gpr68^tm1.1Yaxu mice compared to Gpr68^tm1Yaxu/Gpr68^tm1Yaxu mice

immune system

abnormal osteoclast differentiation ( J:149315 )

• more osteoclasts form in vitro from bone marrow cells than from Gpr68^tm1.1Yaxu cells from a mixed background

decreased monocyte cell number ( J:149315 )

• monocyte numbers are decreased compared to in Gpr68^tm1.1Yaxu homozygotes on a mixed background

abnormal macrophage physiology ( J:149315 )

• LPS-induced nitric oxide (NO) production is more than in similarly treated Gpr68^tm1.1Yaxu homozygotes on a mixed background

abnormal osteoclast physiology ( J:149315 )

• osteoclast survival at pH 6.8 is less than that of osteoclasts from Gpr68^tm1.1Yaxu homozygotes on a mixed background

adipose tissue

abnormal brown adipose tissue morphology ( J:149315 )

• brown adipose tissue is more dense compared to in Gpr68^tm1.1Yaxu homozygotes on a mixed background

decreased brown adipose tissue amount ( J:149315 )

• intrascapular brown adipose tissue deposit exhibit decreased weight and size compared to in Gpr68^tm1.1Yaxu homozygotes on a mixed background

neoplasm

increased tumor growth/size ( J:149315 )

• B16-F10 malignant cells form larger tumors with more blood vessels than tumors that form when B16-F10 malignant cells are transplanted into Gpr68^tm1.1Yaxu homozygotes on a mixed background

skeleton

abnormal osteoclast differentiation ( J:149315 )

• more osteoclasts form in vitro from bone marrow cells than from Gpr68^tm1.1Yaxu cells from a mixed background

abnormal osteoclast physiology ( J:149315 )

• osteoclast survival at pH 6.8 is less than that of osteoclasts from Gpr68^tm1.1Yaxu homozygotes on a mixed background

hematopoietic system

abnormal osteoclast differentiation ( J:149315 )

• more osteoclasts form in vitro from bone marrow cells than from Gpr68^tm1.1Yaxu cells from a mixed background

decreased monocyte cell number ( J:149315 )

• monocyte numbers are decreased compared to in Gpr68^tm1.1Yaxu homozygotes on a mixed background

abnormal macrophage physiology ( J:149315 )

• LPS-induced nitric oxide (NO) production is more than in similarly treated Gpr68^tm1.1Yaxu homozygotes on a mixed background

abnormal osteoclast physiology ( J:149315 )

• osteoclast survival at pH 6.8 is less than that of osteoclasts from Gpr68^tm1.1Yaxu homozygotes on a mixed background

cellular

abnormal osteoclast differentiation ( J:149315 )

• more osteoclasts form in vitro from bone marrow cells than from Gpr68^tm1.1Yaxu cells from a mixed background