About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3849442
Allelic
Composition
Arsbm1J/Arsbm1J
Genetic
Background
C57BL/6J-Arsbm1J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arsbm1J mutation (1 available); any Arsb mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Arsbm1J/Arsbm1J mice (left) exhibit a shortened snout, wide-set eyes and shortened limbs

behavior/neurological

craniofacial

vision/eye

limbs/digits/tail
• thicker digits
• shortened limbs become more noticeable with age

adipose tissue

growth/size/body

skeleton
• greater whole body bone mineral density

hearing/vestibular/ear
• ABR indicative of severe hearing loss

reproductive system
• although both females and males reproduce, small litters and poor breeding have occurred

muscle
• focal muscle degeneration is found in an 8 month old

nervous system
• an 8 month old homozygote shows peripheral nerve degeneration with macrophage infiltration and a 14 month old shows peripheral nerve degeneration with spinal arthritis and vacuoles in the connective tissue around the spine

cellular

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
mucopolysaccharidosis VI DOID:12800 OMIM:253200
J:149960


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory