Mouse Genome Informatics
hm
    Arsbm1J/Arsbm1J
C57BL/6J-Arsbm1J/GrsrJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Arsbm1J/Arsbm1J mice (left) exhibit a shortened snout, wide-set eyes and shortened limbs

behavior/neurological

craniofacial

vision/eye

limbs/digits/tail
• thicker digits
• shortened limbs become more noticeable with age

adipose tissue

growth/size/body

skeleton
• greater whole body bone mineral density

hearing/vestibular/ear
• ABR indicative of severe hearing loss

reproductive system
• although both females and males reproduce, small litters and poor breeding have occurred

muscle
• focal muscle degeneration is found in an 8 month old

nervous system
• an 8 month old homozygote shows peripheral nerve degeneration with macrophage infiltration and a 14 month old shows peripheral nerve degeneration with spinal arthritis and vacuoles in the connective tissue around the spine

cellular

Mouse Models of Human Disease
OMIM IDRef(s)
Mucopolysaccharidosis Type VI; MPS6 253200 J:149960