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Phenotypes Associated with This Genotype
Genotype
MGI:3849442
Allelic
Composition
Arsbm1J/Arsbm1J
Genetic
Background
C57BL/6J-Arsbm1J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arsbm1J mutation (1 available); any Arsb mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Arsbm1J/Arsbm1J mice (left) exhibit a shortened snout, wide-set eyes and shortened limbs

behavior/neurological

craniofacial

vision/eye

limbs/digits/tail
• thicker digits
• shortened limbs become more noticeable with age

adipose tissue

growth/size/body

skeleton
• greater whole body bone mineral density

hearing/vestibular/ear
• ABR indicative of severe hearing loss

reproductive system
• although both females and males reproduce, small litters and poor breeding have occurred

muscle
• focal muscle degeneration is found in an 8 month old

nervous system
• an 8 month old homozygote shows peripheral nerve degeneration with macrophage infiltration and a 14 month old shows peripheral nerve degeneration with spinal arthritis and vacuoles in the connective tissue around the spine

cellular

Mouse Models of Human Disease
OMIM ID Ref(s)
Mucopolysaccharidosis Type VI; MPS6 253200 J:149960


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory