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Phenotypes Associated with This Genotype
Genotype
MGI:3849424
Allelic
Composition
Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic
Background
B6.Cg-Mecomtm1.1Miku
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecomtm1.1Miku mutation (0 available); any Mecom mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• yolk sacs show defective large vessel development
• yolk sacs of E13.5 embyros show severe anemia

hematopoietic system
• fetal liver cells fail to rescue lethally irradiated mice as wild-type fetal liver cells do
• no mutant cells are detected in competitive reconstitution assays
• less HSC are cultured from E9.5 para-aortic splanchnopleural region explants compared to controls
• the population of lin- Kit+CD34+ found among E14.5 fetal liver cells is virtually absent
• the number of CFUs isolated from fetal liver is also severely diminished

cardiovascular system
• yolk sacs show defective large vessel development
• many E13.5 embryos exhibit hemorrhaging

homeostasis/metabolism
• many E13.5 embryos exhibit subcutaneous edema

integument
• many E13.5 embryos exhibit subcutaneous edema


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory