Phenotypes Associated with This Genotype

Genotype
MGI:3848933

• Allelic Composition: Cdx2^tm1Khk/Cdx2^tm1Khk; Tg(Foxa3-cre)1Khk/0
• Genetic Background: involves: C57BL/6 * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:149479 )

• mice die by P1

digestive/alimentary system

abnormal digestive system development ( J:149479 )

• at E14.5, mice exhibit a progressive defects in elongation compared with wild-type mice

• at E14.5, distal intestine contains a dilated gut lumen unlike in wild-type mice

abnormal hindgut morphology ( J:149479 )

• posterior gut region abnormalities are evident as early as E12.5

abnormal enteroendocrine cell morphology ( J:149479 )

• terminal differentiation is severely impaired

abnormal intestine morphology ( J:149479 )

• the intestine ends in an abnormal distal structure that terminates in a blind-sac

• mice exhibit intestinal obstruction unlike in wild-type mice

• at E16.5, mice exhibit a severe shortening of the intestine unlike in wild-type mice

• the posterior intestine is anteriorized

abnormal intestinal goblet cell morphology ( J:149479 )

• terminal differentiation is severely impaired

abnormal intestinal epithelium morphology ( J:149479 )

• proximal and medial intestinal epithelia is less organized compared to in wild-type mice

• the cuboidal epithelia of the jejunum and ileum is replaced with a flattened epithelium

• duodenum epithelial cell proliferation is increased more than 20% compared to in wild-type mice

• however, apoptosis rates of duodenum epithelial cells are normal

• differentiation of gastric glandular epithelial cells cannot be detected

• posterior intestinal epithelial cells contain tonofilaments unlike in wild-type cells

absent enterocytes ( J:149479 )

• terminal differentiation is severely impaired

abnormal cecum morphology ( J:149479 )

• the mutant ileum and cecum lack villi entirely

absent colon ( J:149479 )

• no colon forms

abnormal duodenum morphology ( J:149479 )

• the duodenum contains villus-like epithelial foldings that are stunted and broadened compared to in wild-type mice

• duodenum epithelial cell proliferation is increased more than 20% compared to in wild-type mice

• however, apoptosis rates of duodenum epithelial cells are normal

distended duodenum ( J:149479 )

• the duodenum becomes progressively distended and translucent likely due to fluid retention caused by distal obstruction

• by E18.5, the duodenum is dilated 5- to 7-fold compared to in wild-type mice

decreased small intestinal villus size ( J:149479 )

• at E16.5, mice exhibit villus hypoplasia

• at E18.5, reduced villus increases in severity from anterior to posterior

• the mutant ileum and cecum lack villi entirely

cellular

abnormal intestinal goblet cell morphology ( J:149479 )

• terminal differentiation is severely impaired