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Phenotypes Associated with This Genotype
Genotype
MGI:3848459
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (108 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes

neoplasm
increased intestinal adenocarcinoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 56% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory