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Phenotypes Associated with This Genotype
Genotype
MGI:3847312
Allelic
Composition
SpastM1Gri/SpastM1Gri
Genetic
Background
B6.C-SpastM1Gri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SpastM1Gri mutation (0 available); any Spast mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit axonal swelling containing stalled cargoes in cortical neurons unlike in wild-type mice
• however, axonal branching is normal
• anterograde axonal transport of mitochondria is reduced 25% and anterograde of APP-marked membrane bound organelles is decreased compared to in wild-type mice

behavior/neurological
• at 7 and 12 months, mice exhibit increase in the hind limb base of support compared with wild-type mice
• however, mice exhibit normal muscle strength and motor coordination

Mouse Models of Human Disease
OMIM ID Ref(s)
Spastic Paraplegia 4, Autosomal Dominant; SPG4 182601 J:148877


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory