Mouse Genome Informatics
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    SpastM1Gri/SpastM1Gri
B6.C-SpastM1Gri
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit axonal swelling containing stalled cargoes in cortical neurons unlike in wild-type mice
• however, axonal branching is normal
• anterograde axonal transport of mitochondria is reduced 25% and anterograde of APP-marked membrane bound organelles is decreased compared to in wild-type mice

behavior/neurological
• at 7 and 12 months, mice exhibit increase in the hind limb base of support compared with wild-type mice
• however, mice exhibit normal muscle strength and motor coordination

Mouse Models of Human Disease
OMIM IDRef(s)
Spastic Paraplegia 4, Autosomal Dominant; SPG4 182601 J:148877