Phenotypes Associated with This Genotype

Genotype
MGI:3847120

• Allelic Composition: Lepr^brta/Lepr^brta
• Genetic Background: C57BL/6JSfdAnu-Lepr^brta/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:104190 )

• mice homozygous for this mutation develop severe obesity that is evident by the time they are 4-8 weeks of age

homeostasis/metabolism

hyperglycemia ( J:104190 )

• homozygous mutant mice develop diabetes by 6 weeks of age

reproductive system

infertility ( J:104190 )

• homozygous mutants do not breed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:104190
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:104190