Phenotypes Associated with This Genotype

Genotype
MGI:3846755

• Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:148747 )

• mice die by three weeks of age from a rampant wasting autoimmune disease

immune system

abnormal T cell activation ( J:148747 )

• more T cells in these mice are in an activated state with CD69 and CD44 upregulated and CD62L downregulated

autoimmune response ( J:148747 )

• mice suffer from a generalized autoimmune disease

liver inflammation ( J:148747 )

• liver inflammation occurs in these mice before death

• portal tracts are enlarged, contain congested vessels, and are infiltrated by numerous lymphocytes

liver/biliary system

liver inflammation ( J:148747 )

• liver inflammation occurs in these mice before death

• portal tracts are enlarged, contain congested vessels, and are infiltrated by numerous lymphocytes

hematopoietic system

abnormal T cell activation ( J:148747 )

• more T cells in these mice are in an activated state with CD69 and CD44 upregulated and CD62L downregulated