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Phenotypes Associated with This Genotype
Genotype
MGI:3845817
Allelic
Composition		 Apctm1Cip/Apc+
H19tm1Lda/H19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (156 available)
H19tm1Lda mutation (1 available); any H19 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenocarcinoma incidence ( J:138826 )
• some adenocarcinoma in situ in the intestines
increased adenoma incidence ( J:138826 )
• mice exhibit a 2.2-fold increase in the number of adenomas compared to in Apctm1Cip heterozygotes

digestive/alimentary system
colon polyps ( J:138826 )
• mice exhibit a 3-fold increase in the number of small polyps compared to in Apctm1Cip heterozygotes
increased intestinal adenocarcinoma incidence ( J:138826 )
• some adenocarcinoma in situ in the intestines

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory