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Phenotypes Associated with This Genotype
Genotype
MGI:3845794
Allelic
Composition
Tg(PMP22)C22Clh/0
Genetic
Background
involves: C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(PMP22)C22Clh mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 6 male mice die suddenly between 2 and 5 months of age

reproductive system
• male mice rarely mate

behavior/neurological
• at 3 weeks of age, mice shake when held in the air unlike wild-type mice
• at 3 weeks of age, mice react more than normal mice to sudden noises and other disturbances
• at 3 weeks of age, mice are unsteady when walking unlike wild-type mice
• mice progressively lose control of their hind legs

Mouse Models of Human Disease
OMIM ID Ref(s)
Charcot-Marie-Tooth Disease, Demyelinating, Type 1A; CMT1A 118220 J:78221


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory