Mouse Genome Informatics
tg
    Tg(PMP22)C22Clh/0
involves: C57BL/6 * CBA/Ca
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 6 male mice die suddenly between 2 and 5 months of age

reproductive system
• male mice rarely mate (J:78221)

behavior/neurological
• at 3 weeks of age, mice shake when held in the air unlike wild-type mice
• at 3 weeks of age, mice react more than normal mice to sudden noises and other disturbances
• at 3 weeks of age, mice are unsteady when walking unlike wild-type mice
• mice progressively lose control of their hind legs

Mouse Models of Human Disease
OMIM IDRef(s)
Charcot-Marie-Tooth Disease, Demyelinating, Type 1A; CMT1A 118220 J:78221