Phenotypes Associated with This Genotype

Genotype
MGI:3845660

• Allelic Composition: Otx1^tm1Asim/Otx1^tm1Asim
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:52989 )

• mice exhibit prolonged seizures in the hippocampus and cortex

abnormal telencephalon development ( J:52989 )

• cell proliferation in the dorsal telencephalon is decreased compared to in Otx1^{tm3(OTX2)Asim} homozygotes

decreased brain size ( J:52989 )

• by 25% to 30%

decreased brain weight ( J:52989 )

• by 25% to 30%

abnormal cerebral cortex morphology ( J:52989 )

• the dorsal telencephalic cortex is reduced in thickness and cell number, especially in the temporal and perirhinal areas, compared to in wild-type mice

• cell layers of the cortex are disorganized in the temporal and perirhinal areas where the sulcus rhinalis is hardly recognizable

mortality/aging

premature death ( J:47322 )

• 80% lethality

vision/eye

absent lacrimal glands ( J:52989 )

absent ciliary process ( J:52989 )

• the ciliary process is absent

hearing/vestibular/ear

abnormal inner ear morphology ( J:52989 )

absent lateral semicircular canal ( J:52989 )

behavior/neurological

seizures ( J:52989 )

• mice exhibit prolonged seizures in the hippocampus and cortex

endocrine/exocrine glands

absent lacrimal glands ( J:52989 )

absent Harderian gland ( J:52989 )