Phenotypes Associated with This Genotype

Genotype
MGI:3845086

• Allelic Composition: Phox2a^tm1Jbr/Phox2a^tm1Jbr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal autonomic nervous system morphology ( J:39084 )

abnormal parasympathetic ganglion morphology ( J:39084 )

abnormal otic ganglion morphology ( J:39084 )

• absent

abnormal pterygopalatine ganglion morphology ( J:39084 )

• absent

small submandibular ganglion ( J:39084 )

• sometimes reduced

small superior cervical ganglion ( J:39084 )

• reduced in size at E13.5 and a second cervical ganglion is present

• size difference is not significant at birth

abnormal locus ceruleus morphology ( J:39084 )

• absent

abnormal cranial ganglia morphology ( J:39084 )

small geniculate ganglion ( J:39084 )

• at E13.5

• normal at E10.5

small petrosal ganglion ( J:39084 )

• massive apoptosis at E11.5

• severely reduced by 77% at E13.5

• normal at E10.5

small nodose ganglion ( J:39084 )

• massive apoptosis at E11.5

• severely reduced by 77% at E13.5

• normal at E10.5