Phenotypes Associated with This Genotype

Genotype
MGI:3844572

• Allelic Composition: Elf5^tm1Sin/Elf5⁺; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition only a low density of lobuloalveolar like structures are seen and only a few of these display features of secretory differentiation in the lumina instead most lumina are filled with condensed secretory materials

♀ • the presence of condensed secretory materials suggests that mammary epithelial cells fail to undergo terminal differentiation

♀ • after multiple pregnancies lobuloalveolar development is partially restored

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition only a low density of lobuloalveolar like structures are seen and only a few of these display features of secretory differentiation in the lumina instead most lumina are filled with condensed secretory materials

♀ • the presence of condensed secretory materials suggests that mammary epithelial cells fail to undergo terminal differentiation

♀ • after multiple pregnancies lobuloalveolar development is partially restored

abnormal lactation ( J:148362 )

♀ • unable to lactate after the first pregnancy

♀ • females are often able to lactate after multiple pregnancies

integument

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition only a low density of lobuloalveolar like structures are seen and only a few of these display features of secretory differentiation in the lumina instead most lumina are filled with condensed secretory materials

♀ • the presence of condensed secretory materials suggests that mammary epithelial cells fail to undergo terminal differentiation

♀ • after multiple pregnancies lobuloalveolar development is partially restored

abnormal lactation ( J:148362 )

♀ • unable to lactate after the first pregnancy

♀ • females are often able to lactate after multiple pregnancies