Phenotypes Associated with This Genotype

Genotype
MGI:3844571

• Allelic Composition: Elf5^tm1Sin/Elf5^tm1Sin; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:148362 )

N • unlike homozygous mice carrying Tg(MMTV-cre)4Mam , viability of mutants is similar to controls

reproductive system

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition no lobuloalveolar like structures are present and mammary tissue is still composed primarily of adipocytes

♀ • at parturition even after multiple pregnancies the majority of the epithelial architecture displays closed lumens

♀ • at parturition mammary epithelial cells retain characteristics of virgin ductal epithelial cells

♀ • mammary epithelial cells fail to proliferate and fail to undergo functional differentiation

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition no lobuloalveolar like structures are present and mammary tissue is still composed primarily of adipocytes

♀ • at parturition even after multiple pregnancies the majority of the epithelial architecture displays closed lumens

♀ • at parturition mammary epithelial cells retain characteristics of virgin ductal epithelial cells

♀ • mammary epithelial cells fail to proliferate and fail to undergo functional differentiation

lactation failure ( J:148362 )

♀ • unable to lactate even after multiple pregnancies

integument

integument phenotype ( J:148362 )

N • despite recombination in the skin, no gross skin abnormalities are detected

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition no lobuloalveolar like structures are present and mammary tissue is still composed primarily of adipocytes

♀ • at parturition even after multiple pregnancies the majority of the epithelial architecture displays closed lumens

♀ • at parturition mammary epithelial cells retain characteristics of virgin ductal epithelial cells

♀ • mammary epithelial cells fail to proliferate and fail to undergo functional differentiation

lactation failure ( J:148362 )

♀ • unable to lactate even after multiple pregnancies