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Phenotypes Associated with This Genotype
Genotype
MGI:3843626
Allelic
Composition
Lig1tm1Dwm/Lig1tm1Dwm
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig1tm1Dwm mutation (0 available); any Lig1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• fibroblasts exhibit normal nucleotide excision repair, repair of alkylation damage, sensitivity to 3-aminobenzamide, repair of ionizing radiation damage, and sister chromatid exchange rates
• cultured fibroblasts grow more slowly than wild-type cells
• fibroblasts accumulate replication intermediates unlike in wild-type cells
• fibroblasts exhibit increased chromosomal instability compared to wild-type cells

hematopoietic system
• when fetal liver cells are used to rescue lethally irradiated mice
• when fetal liver cells are used to rescue lethally irradiated mice, fetal liver cells contribute to all lineages but in lower numbers than when wild-type cells are used to rescue lethally irradiated mice
• when fetal liver cells are used to rescue lethally irradiated mice
• when fetal liver cells are used to rescue lethally irradiated mice
• when fetal liver cells are used to rescue lethally irradiated mice
• when fetal liver cells are used to rescue lethally irradiated mice
• when fetal liver cells are used to rescue lethally irradiated mice

homeostasis/metabolism
• fibroblasts accumulate replication intermediates unlike in wild-type cells

immune system
• when fetal liver cells are used to rescue lethally irradiated mice

growth/size/body
• when fetal liver cells are used to rescue lethally irradiated mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory