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Phenotypes Associated with This Genotype
Genotype
MGI:3843606
Allelic
Composition
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (121 available)
Tg(RIP1-Tag)2Dh mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 13 week old mice have a mean of 7 tumors with an average volume greater than 40 mm3
• there is a significantly lower proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics where cre-mediated recombination of Bcl2l1 occurs in pancreatic beta cells

neoplasm
• 13 week old mice have a mean of 7 tumors with an average volume greater than 40 mm3
• there is a significantly lower proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics where cre-mediated recombination of Bcl2l1 occurs in pancreatic beta cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:146436


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/08/2020
MGI 6.15
The Jackson Laboratory