Mouse Genome Informatics
ht
    Avptm1Lja/Avp+
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• seen at 6 months of age

renal/urinary system
• progressive increase in urine volume beginning by 1 month of age

nervous system
• decrease in the number of vasopressinergic neurons beginning at 2 months of age with near total loss by 18 months of age
• expression analysis suggests increased endoplasmic reticulum stress in vasopressinergic neurons

homeostasis/metabolism
• at 3, 6, 9, and 12 months of age circulating arginine vasopressin levels are decreased
• at 1 month of age following 24 hour water deprivation circulating arginine vasopressin levels are only 20% that of wild-type controls

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Insipidus, Neurohypophyseal 125700 J:148012