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Phenotypes Associated with This Genotype
Genotype
MGI:3843462
Allelic
Composition
Avptm1Lja/Avp+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avptm1Lja mutation (0 available); any Avp mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seen at 6 months of age

renal/urinary system
• progressive increase in urine volume beginning by 1 month of age

nervous system
• decrease in the number of vasopressinergic neurons beginning at 2 months of age with near total loss by 18 months of age
• expression analysis suggests increased endoplasmic reticulum stress in vasopressinergic neurons

homeostasis/metabolism
• at 3, 6, 9, and 12 months of age circulating arginine vasopressin levels are decreased
• at 1 month of age following 24 hour water deprivation circulating arginine vasopressin levels are only 20% that of wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neurohypophyseal diabetes insipidus DOID:12388 OMIM:125700
OMIM:304900
J:148012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory