About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3843462
Allelic
Composition
Avptm1Lja/Avp+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avptm1Lja mutation (0 available); any Avp mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seen at 6 months of age

renal/urinary system
• progressive increase in urine volume beginning by 1 month of age

nervous system
• decrease in the number of vasopressinergic neurons beginning at 2 months of age with near total loss by 18 months of age
• expression analysis suggests increased endoplasmic reticulum stress in vasopressinergic neurons

homeostasis/metabolism
• at 3, 6, 9, and 12 months of age circulating arginine vasopressin levels are decreased
• at 1 month of age following 24 hour water deprivation circulating arginine vasopressin levels are only 20% that of wild-type controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Insipidus, Neurohypophyseal 125700 J:148012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory