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Phenotypes Associated with This Genotype
Genotype
MGI:3843460
Allelic
Composition
Avptm1Hari/Avp+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avptm1Hari mutation (0 available); any Avp mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• accompanies increased urine output
• increase in water intake is more severe in females than in males
• increase in water intake decreases in ovariectomized females

homeostasis/metabolism
• progressive decline in pituitary arginine vasopressin levels beginning by 1 month of age
• decrease in pituitary arginine vasopressin levels is more severe in females than in males
• progressive decline in urine osmolality beginning by 1 month of age
• decrease in urine osmolality is more severe in females than in males
• decrease in urine osmolality decreases in ovariectomized females

renal/urinary system
• progressive decline in urine osmolality beginning by 1 month of age
• decrease in urine osmolality is more severe in females than in males
• decrease in urine osmolality decreases in ovariectomized females
• progressive increase in urine volume beginning by 1 month of age
• polyuria is more severe in females than in males
• increase in urine volume decreases in ovariectomized females

nervous system
• at 6 and 12 months of age, round inclusion bodies are seen
• the number and size of inclusions increases with age in males, while the size of inclusions increases with age but the number decreases in females
• the number of arginine vasopressin expressing neurons is decreased in females at 12 months of age
• at 1 month of age aggregates are seen in the lumen of the endoplasmic reticulum and to a lesser extent in the nucleus of arginine vasopressin expressing neurons

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Insipidus, Neurohypophyseal 125700 J:147993


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory