Mouse Genome Informatics
ht
    Avptm1Hari/Avp+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• accompanies increased urine output
• increase in water intake is more severe in females than in males
• increase in water intake decreases in ovariectomized females

homeostasis/metabolism
• progressive decline in pituitary arginine vasopressin levels beginning by 1 month of age
• decrease in pituitary arginine vasopressin levels is more severe in females than in males
• progressive decline in urine osmolality beginning by 1 month of age
• decrease in urine osmolality is more severe in females than in males
• decrease in urine osmolality decreases in ovariectomized females

renal/urinary system
• progressive decline in urine osmolality beginning by 1 month of age
• decrease in urine osmolality is more severe in females than in males
• decrease in urine osmolality decreases in ovariectomized females
• progressive increase in urine volume beginning by 1 month of age
• polyuria is more severe in females than in males
• increase in urine volume decreases in ovariectomized females

nervous system
• at 6 and 12 months of age, round inclusion bodies are seen
• the number and size of inclusions increases with age in males, while the size of inclusions increases with age but the number decreases in females
• the number of arginine vasopressin expressing neurons is decreased in females at 12 months of age
• at 1 month of age aggregates are seen in the lumen of the endoplasmic reticulum and to a lesser extent in the nucleus of arginine vasopressin expressing neurons

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Insipidus, Neurohypophyseal 125700 J:147993