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Phenotypes Associated with This Genotype
Genotype
MGI:3843203
Allelic
Composition
Men1tm1Ctre/Men1tm1Ctre
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1Ctre mutation (0 available); any Men1 mutation (17 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice are dead by 14 months of age unlike wild-type mice

endocrine/exocrine glands
• at 3 and 12 months, the vasculature of some islets is abnormal with dilation of blood vessels and intense tortuosity unlike in wild-type mice
• however, treatment with sunitinib decreases in islet vascularity
• as early as 5 to 6 months
• as early as 5 to 6 months
• by 10 to 12 months of age, mice develop insulinoma that are filled with blood islands or lacunae unlike wild-type mice
• however, mice do not develop gastrinoma unlike in other MEN1 models
• mice exhibit more proliferating cells within their islets compared with wild-type mice
• however, proliferation of exocrine cells is normal and treatment with sunitinib decreases islet cell proliferation

homeostasis/metabolism
• at 10 months of age
• starting at 5 months of age

neoplasm
• by 10 to 12 months of age, mice develop insulinoma that are filled with blood islands or lacunae unlike wild-type mice
• however, mice do not develop gastrinoma unlike in other MEN1 models

cardiovascular system
• at 3 and 12 months, the vasculature of some islets is abnormal with dilation of blood vessels and intense tortuosity unlike in wild-type mice
• however, treatment with sunitinib decreases in islet vascularity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple endocrine neoplasia type 1 DOID:10017 OMIM:131100
J:146440


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory