Phenotypes Associated with This Genotype

Genotype
MGI:3842959

• Allelic Composition: Tg(KRT5-tTA)1216Glk/0; Tg(tetO-Tek)1Dmt/0
• Genetic Background: involves: CD-1 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased interferon-gamma secretion ( J:147438 )

• is increased in the ear and back skin of mice

abnormal interleukin secretion ( J:147438 )

• interleukin-22 secretion is increased in the ear and back skin of mice

increased interleukin-12 secretion ( J:147438 )

• is increased in the ear and back skin of mice

increased interleukin-17 secretion ( J:147438 )

• is increased in the ear and back skin of mice

increased interleukin-23 secretion ( J:147438 )

• is increased in the ear and back skin of mice

skin inflammation ( J:147438 )

• inflammatory infiltrate associated with psoriasis includes CD4⁺ T cells in the dermis and CD8⁺ T cells in the epidermis, myeloid dendritic cells, macrophages and granulocytes

cardiovascular system

abnormal vascular branching morphogenesis ( J:147438 )

• mouse ears by 21 days of age contain larger blood vessels that are more highly branched

• a similar trend is observed for vessels in both dorsal and ventral superficial fascia

increased angiogenesis ( J:147438 )

• ears contain 59% more blood vessels and back skin 102% more blood vessels than controls

integument

skin inflammation ( J:147438 )

• inflammatory infiltrate associated with psoriasis includes CD4⁺ T cells in the dermis and CD8⁺ T cells in the epidermis, myeloid dendritic cells, macrophages and granulocytes

acanthosis ( J:147438 )

• is observed in the skin and back

reddish skin ( J:147438 )

• mouse ears are erythematous by 21 days of age

psoriasis ( J:147438 )

• skin begins to develop reddened, scaly, hyperkeratotic lesions between 2 to 6 months of age

• lesions involve hyperplasia of the epidermis, a loss of the granular cell layer, thickening of the interfollicular epidermal layers, confluent parakeratotic scale, increased dermal angiogenesis, and extensive inflammatory infiltration

• dorsal and ventral surfaces, bilateral elbows, and skin surrounding the genital region can develop these lesion

• 73% of mice have lesions involving back and ear, 22% develop just ear lesions, and 5% develop no lesions

• psoriasis can be reversed by treatment with doxycycline or attenuated with cyclosporine A treatment

thick skin ( J:147438 )

• the epidermis is 3.2- and 3.1- fold thicker in the ear and backs, respectively, than in controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:147438