Mouse Genome Informatics
cn
    Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Trp53tm1Brn/Trp53tm1Brn

involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• proliferation is increased in oral tumors compared to in Tg(KRT5-Akt1*)Jmpa oral tumors
• the number of blood vessels is enhanced in dysplasias and tumors compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice
• mice develop malignant carcinomas in the oral cavity affecting the palate, ventral side of the tongue, and the external and internal sides of the lips unlike in wild-type mice
• mice develop tumors earlier than in mice expressing Trp53
• mice develop lymph node metastases and lung micrometastases from undifferentiated highly aggressive primary tumors

cellular
• cell proliferation of nonlesion oral epithelia is greater than in wild-type and Tg(KRT5-Akt1*)Jmpa mice
• oral keratinocyte proliferation is greater than in wild-type cells

integument
• oral keratinocyte proliferation is greater than in wild-type cells

Mouse Models of Human Disease
OMIM IDRef(s)
Squamous Cell Carcinoma, Head and Neck; HNSCC 275355 J:144831