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Phenotypes Associated with This Genotype
Genotype
MGI:3842833
Allelic
Composition
Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)8Brn mutation (4 available)
Tg(KRT5-Akt1*)Jmpa mutation (0 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (147 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• proliferation is increased in oral tumors compared to in Tg(KRT5-Akt1*)Jmpa oral tumors
• the number of blood vessels is enhanced in dysplasias and tumors compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice
• mice develop malignant carcinomas in the oral cavity affecting the palate, ventral side of the tongue, and the external and internal sides of the lips unlike in wild-type mice
• mice develop tumors earlier than in mice expressing Trp53
• mice develop lymph node metastases and lung micrometastases from undifferentiated highly aggressive primary tumors

cellular
• cell proliferation of nonlesion oral epithelia is greater than in wild-type and Tg(KRT5-Akt1*)Jmpa mice
• oral keratinocyte proliferation is greater than in wild-type cells

integument
• oral keratinocyte proliferation is greater than in wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Squamous Cell Carcinoma, Head and Neck; HNSCC 275355 J:144831


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory