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Phenotypes Associated with This Genotype
Genotype
MGI:3842791
Allelic
Composition
Tg(Ckm-IGF1R*K1003R)1Dlr/0
Genetic
Background
FVB/N-Tg(Ckm-IGF1R*K1003R)1Dlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckm-IGF1R*K1003R)1Dlr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice subjected to uninephrectomy exhibit increased serum creatinine compared to wild-type mice (J:210518)
• mice subjected to uninephrectomy exhibit increased serum creatinine compared to wild-type mice (J:210518)
• serum cholesterol is increased; diet has no effect on cholesterol levels (J:210518)
• serum cholesterol is increased; diet has no effect on cholesterol levels (J:210518)
• 2-fold at 3 to 4 weeks of age (J:71205)
• 2-fold at 3 to 4 weeks of age (J:71205)
• 2-fold at 3 to 4 weeks of age (J:71205)
• 2-fold at 3 to 4 weeks of age (J:71205)
• total body glucose disposal, glycolysis, and glycogen synthesis are reduced compared to in wild-type mice (J:71205)
• total body glucose disposal, glycolysis, and glycogen synthesis are reduced compared to in wild-type mice (J:71205)
• seen in mice fed a regular chow diet (J:210518)
• mice subjected to uninephrectomy remain hyperglycemic (J:210518)
• seen in mice fed a regular chow diet (J:210518)
• mice subjected to uninephrectomy remain hyperglycemic (J:210518)
• at 2 weeks of age (J:71205)
• at 2 weeks of age (J:71205)
• at 7 to 12 weeks (J:71205)
• at 7 to 12 weeks (J:71205)
• glycogen synthesis is reduced compared to in wild-type mice (J:71205)
• glycogen synthesis is reduced compared to in wild-type mice (J:71205)
• mice exhibit albuminuria at 30 weeks of age (J:210518)
• after 24 weeks of high-fat diet feeding, mutants exhibit a significant increase in albuminuria than low-fat diet fed mutants (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated albuminuria (J:210518)
• mice exhibit albuminuria at 30 weeks of age (J:210518)
• after 24 weeks of high-fat diet feeding, mutants exhibit a significant increase in albuminuria than low-fat diet fed mutants (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated albuminuria (J:210518)
• following stimulation with IGF-I, muscle fails to exhibit an increase in glucose uptake unlike in similarly treated wild-type muscle (J:71205)
• following stimulation with IGF-I, muscle fails to exhibit an increase in glucose uptake unlike in similarly treated wild-type muscle (J:71205)

muscle
• insulin stimulated glucose uptake is 1.5-fold compared to 5-fold in wild-type mice (J:71205)
• following stimulation with IGF-I, muscle fails to exhibit an increase in glucose uptake unlike in similarly treated wild-type muscle (J:71205)
• insulin stimulated glucose uptake is 1.5-fold compared to 5-fold in wild-type mice (J:71205)
• following stimulation with IGF-I, muscle fails to exhibit an increase in glucose uptake unlike in similarly treated wild-type muscle (J:71205)

endocrine/exocrine glands

cellular
• insulin stimulated glucose uptake is 1.5-fold compared to 5-fold in wild-type mice (J:71205)
• following stimulation with IGF-I, muscle fails to exhibit an increase in glucose uptake unlike in similarly treated wild-type muscle (J:71205)
• insulin stimulated glucose uptake is 1.5-fold compared to 5-fold in wild-type mice (J:71205)
• following stimulation with IGF-I, muscle fails to exhibit an increase in glucose uptake unlike in similarly treated wild-type muscle (J:71205)
• glucose transport activity in skeletal muscle and brown adipose tissue is reduced 50% compared to in wild-type cells (J:71205)
• glucose transport activity in skeletal muscle and brown adipose tissue is reduced 50% compared to in wild-type cells (J:71205)

growth/size/body
• 20% from birth to 4 weeks of age and 10% from 4 weeks of age through adulthood (J:71205)
• 20% from birth to 4 weeks of age and 10% from 4 weeks of age through adulthood (J:71205)
• mice exhibit modest growth retardation from birth to 4 weeks of age and a smaller reduction in growth from 4 weeks of age through adulthood compared to in wild-type mice (J:71205)
• mice exhibit modest growth retardation from birth to 4 weeks of age and a smaller reduction in growth from 4 weeks of age through adulthood compared to in wild-type mice (J:71205)
• mice subjected to uninephrectomy remain hyperglycemic but gain less body weight than wild-type mice (J:210518)
• mice subjected to uninephrectomy remain hyperglycemic but gain less body weight than wild-type mice (J:210518)

liver/biliary system

cardiovascular system
• mice subjected to uninephrectomy exhibit elevated systolic and diastolic blood pressure compared to wild-type mice (J:210518)
• mice subjected to uninephrectomy exhibit elevated systolic and diastolic blood pressure compared to wild-type mice (J:210518)

renal/urinary system
• mice exhibit albuminuria at 30 weeks of age (J:210518)
• after 24 weeks of high-fat diet feeding, mutants exhibit a significant increase in albuminuria than low-fat diet fed mutants (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated albuminuria (J:210518)
• mice exhibit albuminuria at 30 weeks of age (J:210518)
• after 24 weeks of high-fat diet feeding, mutants exhibit a significant increase in albuminuria than low-fat diet fed mutants (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated albuminuria (J:210518)
• mice fed a high-fat diet exhibit foot process effacement (J:210518)
• mice subjected to uninephrectomy exhibit accelerated foot process effacement (J:210518)
• mice fed a high-fat diet exhibit foot process effacement (J:210518)
• mice subjected to uninephrectomy exhibit accelerated foot process effacement (J:210518)
• mice fed a high-fat diet exhibit a decrease in podocyte number (J:210518)
• mice subjected to uninephrectomy exhibit an accelerated decrease in podocyte number (J:210518)
• mice fed a high-fat diet exhibit a decrease in podocyte number (J:210518)
• mice subjected to uninephrectomy exhibit an accelerated decrease in podocyte number (J:210518)
• increase in glomerular basement membrane thickening, regardless of diet (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated basement membrane thickening (J:210518)
• increase in glomerular basement membrane thickening, regardless of diet (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated basement membrane thickening (J:210518)
• mice exhibit glomerular injury at baseline (J:210518)
• increase in glomerular volume, regardless of diet (J:210518)
• mice fed a high-fat diet for 24 weeks exhibit acceleration of glomerulopathy compared to wild-type mice, showing an increase in mesangial expansion, foot process effacement and glomerular basement membrane thickening, and a decrease in podocyte number (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated glomerular injury compared to similarly subjected wild-type mice or to high-fat diet fed mutants, showing increased albuminuria, kidney weight, mesangial expansion, foot process effacement, glomerular volume and glomerular basement membrane thickening and a decrease in podocyte number (J:210518)
• mice exhibit glomerular injury at baseline (J:210518)
• increase in glomerular volume, regardless of diet (J:210518)
• mice fed a high-fat diet for 24 weeks exhibit acceleration of glomerulopathy compared to wild-type mice, showing an increase in mesangial expansion, foot process effacement and glomerular basement membrane thickening, and a decrease in podocyte number (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated glomerular injury compared to similarly subjected wild-type mice or to high-fat diet fed mutants, showing increased albuminuria, kidney weight, mesangial expansion, foot process effacement, glomerular volume and glomerular basement membrane thickening and a decrease in podocyte number (J:210518)
• increase in mesangial expansion, regardless of diet (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated mesangial expansion (J:210518)
• increase in mesangial expansion, regardless of diet (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated mesangial expansion (J:210518)
• larger kidney weight at 30 weeks of age; diet has no effect on kidney weight (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated increase in kidney weight (J:210518)
• larger kidney weight at 30 weeks of age; diet has no effect on kidney weight (J:210518)
• mutants subjected to uninephrectomy exhibit accelerated increase in kidney weight (J:210518)
• glomerular hyperfiltration, as seen with an increase in glomerular filtration rate at 10 weeks of age (J:210518)
• glomerular hyperfiltration, as seen with an increase in glomerular filtration rate at 10 weeks of age (J:210518)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:71205 , J:210518


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory