Phenotypes Associated with This Genotype

Genotype
MGI:3840860

• Allelic Composition: Rev3l^tm1Esp/Rev3l^tm1Esp
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:65200 )

• most embryos appear arrested in development at E7.25-E7.75, although a few embryos appear to develop further; these never exceed the early somite stage (E8-8.5)

embryo

abnormal embryonic tissue morphology ( J:65200 )

• most mutant embryos undergo little intra-embryonic development with a variable reduction of the embryo body, ranging from complete absence to developing up to the 4-6 somite stage

• in contrast, mutant extraembryonic tissues appear similar in size and morphology to controls at all stages examined