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Phenotypes Associated with This Genotype
Genotype
MGI:3840832
Allelic
Composition
Rag1tm1Jsek/Rag1tm1Jsek
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Jsek mutation (0 available); any Rag1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymus cellularity is reduced 20- to a 100-fold in mice 5 to 6 weeks of age (J:146912)
• thymus cellularity is reduced 20- to a 100-fold in mice 5 to 6 weeks of age (J:146912)
• immature B220+IgM+ B cells are absent from the bone marrow (J:146912)
• immature B220+IgM+ B cells are absent from the bone marrow (J:146912)
• IgH-D to IgH-J rearrangements are severely impaired in sorted pro-B- and pre-B-cell populations (J:146912)
• IgH-D to IgH-J rearrangements are severely impaired in sorted pro-B- and pre-B-cell populations (J:146912)
• pro-B cell numbers are increased in the bone marrow due to block in B cell development (J:146912)
• pro-B cell numbers are increased in the bone marrow due to block in B cell development (J:146912)
• B cell development is completely arrested at the B220+CD43+ stage (J:146912)
• B cell development is completely arrested at the B220+CD43+ stage (J:146912)
• interchromosomal trans-rearrangement between Tcrg-variable segments and Tcrb-joining segments are detected in thymocytes (J:146912)
• interchromosomal trans-rearrangement between Tcrg-variable segments and Tcrb-joining segments are detected in thymocytes (J:146912)
• Dbeta to Jbeta rearrangements are severely impaired in thymocytes (J:146912)
• Dbeta to Jbeta rearrangements are severely impaired in thymocytes (J:146912)
• there is an increased percentage of thymocytes at the DN3 (CD44-CD25+) stage (J:146912)
• there is an increased percentage of thymocytes at the DN3 (CD44-CD25+) stage (J:146912)
• a very small number of double-positive T cells are observed in the thymus of most mice (J:146912)
• a minority of mice have no detectable double-positive T cells (J:146912)
• a very small number of double-positive T cells are observed in the thymus of most mice (J:146912)
• a minority of mice have no detectable double-positive T cells (J:146912)
• vast majority of thymocytes arrest development at the DN3 (CD44-CD25+) stage (J:146912)
• vast majority of thymocytes arrest development at the DN3 (CD44-CD25+) stage (J:146912)
• mature B220+IgM+ B cells are absent from the periphery (J:146912)
• mature B220+IgM+ B cells are absent from the periphery (J:146912)
• a very small number of CD4+ T cells are found in the thymus and lymph nodes (J:146912)
• a very small number of CD4+ T cells are found in the thymus and lymph nodes (J:146912)
• a very small number of CD8+ T cells are found in the thymus and lymph nodes (J:146912)
• a very small number of CD8+ T cells are found in the thymus and lymph nodes (J:146912)
• gammadelta T cell numbers are dramatically reduced both in the thymus and in the periphery (J:146912)
• gammadelta T cell numbers are dramatically reduced both in the thymus and in the periphery (J:146912)
• majority of mice have substantially lower levels of IgE (J:146912)
• however, almost a third have mice have IgE levels that are 5- to 10- fold higher than wild-type controls (J:146912)
• majority of mice have substantially lower levels of IgE (J:146912)
• however, almost a third have mice have IgE levels that are 5- to 10- fold higher than wild-type controls (J:146912)

cellular
• interchromosomal trans-rearrangement between Tcrg-variable segments and Tcrb-joining segments are detected in thymocytes (J:146912)
• interchromosomal trans-rearrangement between Tcrg-variable segments and Tcrb-joining segments are detected in thymocytes (J:146912)

hematopoietic system
• thymus cellularity is reduced 20- to a 100-fold in mice 5 to 6 weeks of age (J:146912)
• thymus cellularity is reduced 20- to a 100-fold in mice 5 to 6 weeks of age (J:146912)
• immature B220+IgM+ B cells are absent from the bone marrow (J:146912)
• immature B220+IgM+ B cells are absent from the bone marrow (J:146912)
• IgH-D to IgH-J rearrangements are severely impaired in sorted pro-B- and pre-B-cell populations (J:146912)
• IgH-D to IgH-J rearrangements are severely impaired in sorted pro-B- and pre-B-cell populations (J:146912)
• pro-B cell numbers are increased in the bone marrow due to block in B cell development (J:146912)
• pro-B cell numbers are increased in the bone marrow due to block in B cell development (J:146912)
• B cell development is completely arrested at the B220+CD43+ stage (J:146912)
• B cell development is completely arrested at the B220+CD43+ stage (J:146912)
• interchromosomal trans-rearrangement between Tcrg-variable segments and Tcrb-joining segments are detected in thymocytes (J:146912)
• interchromosomal trans-rearrangement between Tcrg-variable segments and Tcrb-joining segments are detected in thymocytes (J:146912)
• Dbeta to Jbeta rearrangements are severely impaired in thymocytes (J:146912)
• Dbeta to Jbeta rearrangements are severely impaired in thymocytes (J:146912)
• there is an increased percentage of thymocytes at the DN3 (CD44-CD25+) stage (J:146912)
• there is an increased percentage of thymocytes at the DN3 (CD44-CD25+) stage (J:146912)
• a very small number of double-positive T cells are observed in the thymus of most mice (J:146912)
• a minority of mice have no detectable double-positive T cells (J:146912)
• a very small number of double-positive T cells are observed in the thymus of most mice (J:146912)
• a minority of mice have no detectable double-positive T cells (J:146912)
• vast majority of thymocytes arrest development at the DN3 (CD44-CD25+) stage (J:146912)
• vast majority of thymocytes arrest development at the DN3 (CD44-CD25+) stage (J:146912)
• mature B220+IgM+ B cells are absent from the periphery (J:146912)
• mature B220+IgM+ B cells are absent from the periphery (J:146912)
• a very small number of CD4+ T cells are found in the thymus and lymph nodes (J:146912)
• a very small number of CD4+ T cells are found in the thymus and lymph nodes (J:146912)
• a very small number of CD8+ T cells are found in the thymus and lymph nodes (J:146912)
• a very small number of CD8+ T cells are found in the thymus and lymph nodes (J:146912)
• gammadelta T cell numbers are dramatically reduced both in the thymus and in the periphery (J:146912)
• gammadelta T cell numbers are dramatically reduced both in the thymus and in the periphery (J:146912)
• majority of mice have substantially lower levels of IgE (J:146912)
• however, almost a third have mice have IgE levels that are 5- to 10- fold higher than wild-type controls (J:146912)
• majority of mice have substantially lower levels of IgE (J:146912)
• however, almost a third have mice have IgE levels that are 5- to 10- fold higher than wild-type controls (J:146912)

endocrine/exocrine glands
• thymus cellularity is reduced 20- to a 100-fold in mice 5 to 6 weeks of age (J:146912)
• thymus cellularity is reduced 20- to a 100-fold in mice 5 to 6 weeks of age (J:146912)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Omenn Syndrome 603554 J:146912


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory