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Phenotypes Associated with This Genotype
Genotype
MGI:3840340
Allelic
Composition
Muttm1Cpv/Muttm1Cpv
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Muttm1Cpv mutation (0 available); any Mut mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 24 and 36 hours after birth with respiratory distress

homeostasis/metabolism
• at E16.5 and in newborn mice, levels of plasma methylmalonic acid are higher than in wild-type mice
• at 8 to 12 hours of age, mice exhibit methylmalonic acidemia unlike wild-type mice
• 24 hours after birth, mice exhibit a reduction in the stomach milk spot and dehydration unlike wild-type mice
• at 8 to 12 hours of age, mice exhibit methylmalonic aciduria unlike wild-type mice

respiratory system
• in 2 of 8 mice
• 24 and 36 hours after birth

liver/biliary system
• at 24 to 36 hours after birth, mice exhibit non-necrotic lipidotic changes in the liver unlike in wild-type mice

nervous system
• the brain appears compressed against the dura mater unlike in wild-type mice

renal/urinary system
• at 8 to 12 hours of age, mice exhibit methylmalonic aciduria unlike wild-type mice

cardiovascular system
• in 2 of 8 mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory