Mouse Genome Informatics
hm
    Iduatm1Clk/Iduatm1Clk
B6.129-Iduatm1Clk/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• only 21% of males and 40% of females live past 12 months of age
• the median survival age for males is 32 weeks and for females 48 weeks
• the rapid loss of male mice starts around 7 months of age and for females at 9 months of age

growth/size
• body weight of mice becomes significantly greater than controls at 11 weeks of age for females and 14 weeks of age for males
• mice remain heavier for at 34 weeks of age

behavior/neurological
• 8 month old males bury fewer marblesthan controls, which is suggestive of increased anxiety
• control mice 8 months of age spent 66% of the time exploring a novel object whereas the mutant mice only spent 54% of the time exploring the novel object
• mice have less habituation to an open field as determined by less decrease in locomotor activity on the third exposure compared to the first
• 4-month old mice take longer than controls to reach a hidden platform in a morris water maze
• differences were not observed at 2, 6, and 8 months of age
• mice at 4 or 8 months of age swim further away from target than controls both 1 day and 7 days after last learning session in a morris water maze
• 61.0% of mutant mice do no react to an acoustic startle compared to 9.7% of control mice that do not react
• mice have decreased horizontal activity when placed into a new environment

homeostasis/metabolism
• urinary secretion of glycosaminoglycans is 4- to 20-fold higher than controls regardless of age

renal/urinary system
• urinary secretion of glycosaminoglycans is 4- to 20-fold higher than controls regardless of age

Mouse Models of Human Disease
OMIM IDRef(s)
Hurler Syndrome 607014 J:130215