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Phenotypes Associated with This Genotype
Genotype
MGI:3839539
Allelic
Composition
Lpin1fld-2J/Lpin1fld-2J
Genetic
Background
C3H/HeJ-Lpin1fld-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpin1fld-2J mutation (1 available); any Lpin1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• diminished adipose tissue amount, with 50-90% reductions in white and brown fat pad mass
• adipocytes appear immature with small heterozgenous lipid droplets

growth/size/body
• diminished adipose tissue amount, with 50-90% reductions in white and brown fat pad mass

homeostasis/metabolism
• plasma leptin levels are significantly reduced

behavior/neurological
• observed by 3 weeks of age
• unstable gait observed by 3 weeks of age

liver/biliary system
• considerable fatty infiltration is found in newborns

nervous system
• histology reveals peripheral neuropathy after 4 weeks of age

reproductive system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lipodystrophy DOID:811 OMIM:608709
J:66739


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory