Phenotypes Associated with This Genotype

Genotype
MGI:3839239

• Allelic Composition: Gabbr2^tm1Arca/Gabbr2^tm1Arca
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:146953 )

• deaths start to occur around 2 weeks of age

growth/size/body

decreased body weight ( J:146953 )

behavior/neurological

seizures ( J:146953 )

• conspicuous epileptic phenotype

tonic-clonic seizures ( J:146953 )

• partial and then full tonic-clonic seizures

• ictal episodes sometimes provoke sudden death

• duration of bicuculine induced epileptiform activity in CA3 and intervals between bursts are significantly longer than in controls

nervous system

seizures ( J:146953 )

• conspicuous epileptic phenotype

tonic-clonic seizures ( J:146953 )

• partial and then full tonic-clonic seizures

• ictal episodes sometimes provoke sudden death

• duration of bicuculine induced epileptiform activity in CA3 and intervals between bursts are significantly longer than in controls

abnormal inhibitory postsynaptic currents ( J:146953 )

• paired pulse depression of inhibitory postsynaptic currents is significantly smaller than in controls

abnormal inhibitory postsynaptic potential ( J:146953 )

• single shock stimulation in the stratum radiatum area of CA1 in hippocampal slices fails to elicit the slow component of the inhibitory postsynaptic potential