Phenotypes Associated with This Genotype

Genotype
MGI:3838974

• Allelic Composition: Eif2s2^Gt(XH413)Byg/Eif2s2⁺
• Genetic Background: 129-Eif2s2^Gt(XH413)Byg Chr 19^MOLF/Ei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:146879 )

N • despite reduced proliferation of primordial germ cells, mice exhibit normal initial spermatogonial stem cell populations and spermatogenesis

decreased primordial germ cell proliferation ( J:146879 )

• at E16.5, proliferation of primordial germ cells is less than in 129S1/SvImJ-Chr 19/Na mice

• however, the total number of germ cells in the testes at E14.5 and E16.5 is the same as in 129S1/SvImJ-Chr 19/Na mice

decreased testis weight ( J:146879 )

♂ • compared to in 129S1/SvImJ-Chr 19/Na mice at 6 weeks of age

decreased litter size ( J:146879 )

• compared to in 129S1/SvImJ-Chr 19/Na mice

neoplasm

decreased incidence of induced tumors ( J:146879 )

• incidence of testicular germ cell tumors is decreased 2-fold compared to in 129S1/SvImJ-Chr 19/Na mice

endocrine/exocrine glands

decreased testis weight ( J:146879 )

♂ • compared to in 129S1/SvImJ-Chr 19/Na mice at 6 weeks of age

cellular

decreased primordial germ cell proliferation ( J:146879 )

• at E16.5, proliferation of primordial germ cells is less than in 129S1/SvImJ-Chr 19/Na mice

• however, the total number of germ cells in the testes at E14.5 and E16.5 is the same as in 129S1/SvImJ-Chr 19/Na mice