About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3838963
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-DISC1*)1001Plet/0
Genetic
Background
involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-DISC1*)1001Plet mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• spatial memory in females is impaired in probe trials, with females spending less time in the target quadrant where the platform had previously been
• male mutants show higher degree of spontaneous locomotor activity than wild-type littermate controls during a 20-hour period
• male mutants spend significantly less time in non-aggressive social interaction with other males
• males display increased aggressiveness toward other males, with an increase in number of attacks

nervous system
• volume is significantly increased, with no change in total brain volume
• cultured control neurons grow more complex neurite arbors than mutant neurons (for 20-100 um rings centered on neuron soma)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia 9 DOID:0070085 OMIM:604906
J:146881


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory