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Phenotypes Associated with This Genotype
Genotype
MGI:3838352
Allelic
Composition
Agpat2tm1Garg/Agpat2tm1Garg
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agpat2tm1Garg mutation (0 available); any Agpat2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 20% of mice survive past 3 weeks of age
• 80% of mice die by 3 weeks of age with the majority of these mice dieing within the first week of life

homeostasis/metabolism
N
• mice exhibit normal plasma triglyceride, cholesterol levels, creatine kinase and creatinine level, and consumption of oxygen and carbon dioxide
• mice emit 22% more carbon dioxide than wild-type mice
• 24% more than wild-type mice
• the respiratory exchange ratio is reduced, particularly during the dark phase, compared to in wild-type mice
• in female, but not male, mice
• as early as day 1 after birth
• during an oral glucose tolerance test whether fasted or not (J:231617)
• male, but not female, mice exhibit increased glucose clearance compared with wild-type mice
• hyperinsulinic-insulin resistant whether fasted or not (J:231617)
• however, mice exhibit normal glucose tolerance and normal insulin sensitivity in a meal tolerance test (J:231617)
• in female, but not male, mice
• in males but not females
• fatty acid synthesis is increased compared to in wild-type mice
• when fed a low fat diet, mice exhibit decreased serum fatty acid levels compared to similarly treated wild-type mice and mice fed a regular diet
• when fed a standard diet, female mice exhibit decreased serum fatty acid levels compared to in wild-type mice
• male mice exhibit an increase in liver phosphatidyl ethanolamine (PE), phosphatidyl choline (PC), and phosphatidyl serine (PS) levels compared to in wild-type mice
• levels of diacylglyceride are decreased in male mice compared to in wild-type mice
• however, female mice exhibit normal liver phospholipids levels
• triglyceride levels are increased 6.4-fold in males compared to in wild-type mice (J:146649)
• triglyceride levels are increased 2.1-fold in females compared to in wild-type mice (J:146649)
• however, liver triglyceride levels are decreased in low fat diet fed male mice (by 56%) and female mice compared to in mice fed a regular diet (J:146649)
• triglyceride synthesis in hepatocytes is increased compared to in wild-type cells (J:146649)
• in female and male mice (J:231617)

adipose tissue
• white and brown adipose are completely absent
• 2% compared to 24% to 29% in wild-type mice

behavior/neurological
• 3.7 times more than wild-type mice
• in male and female mice
• mice intake 85% more energy than wild-type mice (J:146649)
• in female, but not male, mice (J:231617)
• particularly during the dark phase

liver/biliary system
• triglyceride levels are increased 6.4-fold in males compared to in wild-type mice (J:146649)
• triglyceride levels are increased 2.1-fold in females compared to in wild-type mice (J:146649)
• however, liver triglyceride levels are decreased in low fat diet fed male mice (by 56%) and female mice compared to in mice fed a regular diet (J:146649)
• triglyceride synthesis in hepatocytes is increased compared to in wild-type cells (J:146649)
• in female and male mice (J:231617)
• livers are twice as heavy as in wild-type mice at 8 to 10 weeks of age (J:146649)
• however, liver weights are decreased in low fat diet fed male (by 28%) and female mice compared to mice fed a standard diet (J:146649)
• in female and male mice at 16 weeks (J:231617)

endocrine/exocrine glands

renal/urinary system
• at 8 to 10 weeks of age

hematopoietic system
• at 8 to 10 weeks of age

digestive/alimentary system
• elongated at 8 to 10 weeks of age

immune system
• at 8 to 10 weeks of age

integument

growth/size/body
• in female and male mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital generalized lipodystrophy type 1 DOID:0111135 OMIM:608594
J:146649


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory