Analysis Tools
mortality/aging
|
• all embryos normal at E11.5
• lethality between E11.5 and E13.5
|
cardiovascular system
|
• multiple hemorrhages begin to develop at E12
|
|
• sometimes
|
|
• sometimes
|
|
• hemorrhages mostly in the central nervous system, 100% of E12.5 embryos
• periventricular regions of the striatum, pons, medulla
• intraparenchymal hemorrhage frequent at the ganglia of cranial nerves VII and VIII
|
|
• blood often accumulates in the ventricles
|
cellular
|
• observed in areas susceptible to hemorrhage
|
liver/biliary system
small liver
(
J:36594
)
|
• from E11.5 to E13.5
|
pale liver
(
J:36594
)
|
• few or no erythropoietic cells
• no megakaryocytes
|
hematopoietic system
|
• no definitive hematopoietic cells in the hepatic cords at E11.5-E13.5
• mostly immature yolk sac derived erythrocytes in the circulation at E12.5, about 78%
|
|
• reduced ability of fetal liver and yolk cells to proliferate and differentiate in vitro
|
nervous system
|
• hemorrhages mostly in the central nervous system, 100% of E12.5 embryos
• periventricular regions of the striatum, pons, medulla
• intraparenchymal hemorrhage frequent at the ganglia of cranial nerves VII and VIII
|
|
• blood often accumulates in the ventricles
|
homeostasis/metabolism
|
• sometimes
|
