Mouse Genome Informatics
tg
    Tg(COL1A1)73Prc/0
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• one mouse died shortly after birth (J:31417)
• about 6% of mice die shortly after birth with extensive bone fractures (J:146429)

skeleton
• extensive fractures of the long bones were seen in the mouse that died shortly after birth (J:31417)
• long bone fractures are seen in about 33% of mice (J:146429)
• decreased femur weight
• in the mouse that died shortly after birth (J:31417)
• seen in about 33% of mice (J:146429)
• decreased mineral content in the long bones
• decreased collagen content in the long bones
• reduced mineralization of the skull in the mouse that died shortly after birth
• about 6% of mice die shortly after birth with extensive bone fractures
• about 33% of mice have detectable bone fractures on the day of birth
• in femurs the force to failure and energy to failure are decreased

craniofacial
• on a powdered diet teeth grow abnormally thin and long
• mice on a pelleted diet develop broken teeth
• on a powdered diet fewer broken teeth are seen

growth/size/body
• on a powdered diet teeth grow abnormally thin and long
• mice on a pelleted diet develop broken teeth
• on a powdered diet fewer broken teeth are seen

behavior/neurological
• limbs were limp in the mouse that died shortly after birth

limbs/digits/tail
• decreased femur weight

integument
• thinner skin at birth

Mouse Models of Human Disease
OMIM IDRef(s)
Osteogenesis Imperfecta, Type I 166200 J:146429