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Phenotypes Associated with This Genotype
Genotype
MGI:3838157
Allelic
Composition
Tg(COL1A1)73Prc/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• one mouse died shortly after birth (J:31417)
• one mouse died shortly after birth (J:31417)
• about 6% of mice die shortly after birth with extensive bone fractures (J:146429)
• about 6% of mice die shortly after birth with extensive bone fractures (J:146429)

skeleton
• extensive fractures of the long bones were seen in the mouse that died shortly after birth (J:31417)
• extensive fractures of the long bones were seen in the mouse that died shortly after birth (J:31417)
• long bone fractures are seen in about 33% of mice (J:146429)
• long bone fractures are seen in about 33% of mice (J:146429)
• decreased femur weight (J:146429)
• decreased femur weight (J:146429)
• in the mouse that died shortly after birth (J:31417)
• in the mouse that died shortly after birth (J:31417)
• seen in about 33% of mice (J:146429)
• seen in about 33% of mice (J:146429)
• decreased mineral content in the long bones (J:146429)
• decreased mineral content in the long bones (J:146429)
• decreased collagen content in the long bones (J:146429)
• decreased collagen content in the long bones (J:146429)
• reduced mineralization of the skull in the mouse that died shortly after birth (J:31417)
• reduced mineralization of the skull in the mouse that died shortly after birth (J:31417)
• about 6% of mice die shortly after birth with extensive bone fractures (J:146429)
• about 33% of mice have detectable bone fractures on the day of birth (J:146429)
• in femurs the force to failure and energy to failure are decreased (J:146429)
• about 6% of mice die shortly after birth with extensive bone fractures (J:146429)
• about 33% of mice have detectable bone fractures on the day of birth (J:146429)
• in femurs the force to failure and energy to failure are decreased (J:146429)

craniofacial
• on a powdered diet teeth grow abnormally thin and long (J:146429)
• on a powdered diet teeth grow abnormally thin and long (J:146429)
• mice on a pelleted diet develop broken teeth (J:146429)
• on a powdered diet fewer broken teeth are seen (J:146429)
• mice on a pelleted diet develop broken teeth (J:146429)
• on a powdered diet fewer broken teeth are seen (J:146429)

growth/size/body
• on a powdered diet teeth grow abnormally thin and long (J:146429)
• on a powdered diet teeth grow abnormally thin and long (J:146429)
• mice on a pelleted diet develop broken teeth (J:146429)
• on a powdered diet fewer broken teeth are seen (J:146429)
• mice on a pelleted diet develop broken teeth (J:146429)
• on a powdered diet fewer broken teeth are seen (J:146429)

behavior/neurological
• limbs were limp in the mouse that died shortly after birth (J:31417)
• limbs were limp in the mouse that died shortly after birth (J:31417)

limbs/digits/tail
• decreased femur weight (J:146429)
• decreased femur weight (J:146429)

integument
• thinner skin at birth (J:146429)
• thinner skin at birth (J:146429)

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteogenesis Imperfecta, Type I; OI1 166200 J:146429


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory