Mouse Genome Informatics
tg
    Tg(Myh7-RARA/lacZ)30Mcco/0
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• female mice die before or shortly after delivering a second consecutive pregnancy

reproductive system
• male mice are unable to breed after 4 to 6 months of age (J:146424)

cardiovascular system
• at 2 months of age, mice exhibit myofiber hypertrophy that is more pronounced with age unlike in wild-type mice
• papillary muscles are attenuated
• at 1 to 7 months of age, mice exhibit mild cardiomegaly unlike in wild-type mice
• mice exhibit trabeculations associated with the interior surface of the left ventricle unlike in wild-type mice
• increased size and mass
• biventricular dilation
• maximum rate of pressure development and relaxation rates are reduced compared to in wild-type mice
• the Starling responses in a Frank-Starling relationship graph are compromised with a severe decrease in slope compared to wild-type mice
• the first derivative of the increase in left ventricle systolic pressure with respect to time, a measure of contractility, is decreased 63% compared to in wild-type mice
• fractional shortening and the velocity of fiber shortening are reduced compared to in wild-type mice
• left ventricular contractility is decreased compared to in wild-type hearts
• the first derivative of the decrease in left ventricular systolic pressure with respect to time, a measure of relaxation, is decreased 64% compared to in wild-type hearts
• mice express markers of cardiac failure unlike wild-type mice

homeostasis/metabolism
• large chronic left atria thrombus

muscle
• at 2 months of age, mice exhibit myofiber hypertrophy that is more pronounced with age unlike in wild-type mice
• the first derivative of the increase in left ventricle systolic pressure with respect to time, a measure of contractility, is decreased 63% compared to in wild-type mice
• fractional shortening and the velocity of fiber shortening are reduced compared to in wild-type mice
• left ventricular contractility is decreased compared to in wild-type hearts
• the first derivative of the decrease in left ventricular systolic pressure with respect to time, a measure of relaxation, is decreased 64% compared to in wild-type hearts

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Dilated, 1A; CMD1A 115200 J:146424