Phenotypes Associated with This Genotype

Genotype
MGI:3837456

• Allelic Composition: Mapk13^tm2.1Lex/Mapk13^tm2.1Lex
• Genetic Background: B6.129S5-Mapk13^tm2.1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:146185 )

• islet cells secrete more insulin under basal and glucose-stimulated conditions compared to wild-type cells by direct effect on the exocytotic machinery downstream of calcium influx

• however, treatment with an inhibitor of PKD reverses enhanced insulin secretion

• following treatment with streptozotocin, insulin content in the pancreas is greater than in similarly treated wild-type mice

decreased susceptibility to diet-induced obesity ( J:146185 )

decreased circulating glucose level ( J:146185 )

• after glucose challenge or when treated with streptozotocin, mice exhibit reduced serum glucose levels compared to similarly treated wild-type mice

increased circulating insulin level ( J:146185 )

• after glucose challenge, when fed high fat diet or following treatment with streptozotocin, mice exhibit increased circulating insulin levels compared to similarly treated wild-type mice

improved glucose tolerance ( J:146185 )

• after a 16 hour fast, mice exhibit enhanced glucose tolerance compared to wild-type mice

• both phases of the biphasic insulin response to glucose challenge are enhanced compared to in wild-type mice

• however, treatment with an inhibitor of PKD reverses enhanced glucose tolerance

increased insulin sensitivity ( J:146185 )

• when fed a high fat diet, mice exhibit better insulin sensitivity than similarly treated wild-type mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:146185 )

N • despite increased insulin release, mice exhibit normal beta cell mass, islet architecture, insulin content, glucagon secretion, and volume density and distribution of both pale and dense core secretory granules in beta cells

abnormal pancreatic beta cell physiology ( J:146185 )

• streptozotocin-treated mice exhibit decreased beta cell apoptosis compared to similarly treated wild-type mice

increased insulin secretion ( J:146185 )

• islet cells secrete more insulin under basal and glucose-stimulated conditions compared to wild-type cells by direct effect on the exocytotic machinery downstream of calcium influx

• however, treatment with an inhibitor of PKD reverses enhanced insulin secretion

• following treatment with streptozotocin, insulin content in the pancreas is greater than in similarly treated wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:146185 )