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Phenotypes Associated with This Genotype
Genotype
MGI:3837131
Allelic
Composition		 Traf6tm1.1Mpa/Traf6tm1.1Mpa
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Traf6tm1.1Mpa mutation (0 available); any Traf6 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-6 level ( J:145306 )
• following exposure to acid-induced acute lung injury

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:145306 )
• following exposure to acid-induced acute lung injury
decreased susceptibility to injury ( J:145306 )
• following exposure to acid-induced acute lung injury, mice exhibit alleviated symptoms compared to wild-type mice with decreased changes in elastance and serum IL6 levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory